A review of the 22 nd Annual Congress of the European Association of Urology , 21 - 24 March 2007 , Berlin , Germany
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چکیده
895 Intravesical passive delivery of botulinum A toxin in patients affected by painful bladder syndrome: A pilot study. A. Giannantoni, E. Costantini, S.M. Di Stasi, E. Mearini, F. Santaniello, A. Vianello, M. Porena. In this study, Botox A was administered intravesically as an instillation, not by injection. Unfortunately, due to the molecular weight, botox A could not penetrate intact epithelium to reach the sub-urothelial nerves involved in bladder pain transmission. It was thought that the lack of efficacy might have been due to an inadequate dose and/or no pre-instillation use of substances aimed at increasing permeability of the urothelium.
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تاریخ انتشار 2007